Science

Programme "Scientific projects"

Epigenetic regulation of intestinal stem cell pathophysiology in Drosophila melanogaster: new links to gut inflammation and malignant transformation

School of Medicine, University of Crete

2015

Chronic inflammatory disorders are often associated with an increased risk of developing cancer. A classic example of the connection between inflammation and cancer is the increased risk of colorectal cancer in patients with inflammatory bowel disease. There is considerable evidence that genetic and environmental factors act through epigenetic mechanisms in the development of chronic inflammation, altering the expression of genes involved in signalling pathways, which leads to the transformation of normal stem cells into cancer cells. In this study, by using Drosophila melanogaster as an in vivo experimental model, we plan to identify the tissue-specific contribution of epigenetic changes in induced intestinal damage and the regenerative capacity of intestinal stem cells, aiming to provide novel insights into the complex interplay between environmental stress, genetics, epigenetics, inflammation and cancer.

Coordinator:

Aristides Iliopoulos, University of Crete

Project's Team:

Zoi Veneti, University of Crete

Campus

PO Box 2208

71 003, Vouton Area

Heraklion, Crete

Tel.: 2810 39 48 00 

Fax: 2810 54 21 15

medsec@med.uoc.gr

www.med.uoc.gr

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