Study of epigenetic mechanisms underlying myelofibrosis
Biomedical Research Foundation of the Academy of Athens (BRFAA)
MPNs are clonal disorders of hematopoietic stem cells. The past few years, major progress has been achieved in understanding the pathogenetic mechanisms undelrying those diseases. These studies, have identified somatic mutations and chromosomal rearrangements that implicate tyrosine kinases or various genes that are involved in the epigenetic control of gene expression. The epigenetic machinery comprises DNA methylation and demethylation, methylation of histone and non-histone proteins, plus many others processes. Alterations in genes participating in these processes seem to contribute in the development of leukemic phenotype. This study focuses in further investigating the way epigenetic machinery regulates gene expression in primary myelofibrosis patients that finally convert to acute myeloid leukemia due to mutations in EZH2 and ASXL1 genes and will be carried out utilizing methylation PCR-arrays and other molecular techniques.
This project was evaluated and funded as part of the Foundation’s effort to support research teams with all their members being under 40 years old.
Final report (in Greek)
Katerina Zoi, Specialized Function Scientist II, Biomedical Research Foundation- Academy of Athens - BRFAA
Andreas Giannopoulos, Biologist - Research Candidate, Biomedical Research Foundation- Academy of Athens - BRFAA
Christine Zoi, PhD Candidate, Biomedical Research Foundation- Academy of Athens - BRFAA