Nanogels in regenerative medicine: towards minimally invasive applications in tissue engineering
Department of Chemical Engineering Aristotle University of Thessaloniki
Tissue engineering and regenerative medicine seek to develop new therapies based on three dimensional cell/ matrix constructs and bioactive scaffolds. Important social/economic needs currently drive rapid developments in these fields. Amongst the various types of biomaterials (scaffolds), gels hold a particular prominent place because they recapitulate best the natural extracellular matrix. Novel cartilage therapies in particular are in high demand since over 40% of the population suffer from cartilage degeneration and currently early stage treatments concentrate mainly on pain management. In this project we focus on developing novel self-assembling peptide nanogels that can delivered as monomer fluid solutions and then penetrate into natural tissue or synthetic structures, before self assembling into larger polymeric molecular structures in situ. These materials will be developed to mimick the biomechanical properties of natural tissue leading potentially to a new unique minimally invasive treatment, for operation-free therapies in cartilage regeneration.
Aggeli Amalia, Associate Professor, Department of Chemical Engineering, Aristotle University of Thessaloniki
Thomas Goudoulas, Researcher, Department of Chemical Engineering, Aristotle University of Thessaloniki
Konstantinos Karatasos, Assistant Professor, Department of Chemical Engineering, Aristotle University of Thessaloniki