Elucidating the RNA communication (ΕRΑΤΟ)
"Department of Electrical and Computer Engineering, University of Thessaly
RNA revolution has turned non-coding RNAs (ncRNAs) from dark-matter into a biological research hotspot. NcRNA families, such as microRNAs (miRNAs) and more recently, long non coding RNAs (lncRNAs) are being researched for physiological and pathological implications.
Aim of this proposal is to elucidate the RNA inter-communication while focusing in the role of noncoding RNAs in nucleus and cytoplasm. This knowledge will provide a major breakthrough towards understanding the function of lncRNAs and miRNAs in the cell. The investigation will focus in unveiling the function of miRNA::lncRNA interactions in cytoplasm and understanding the miRNA function in nucleus.
This work includes both computational and experimental approaches and will be applied on erythroid cells. Elucidating the mechanisms by which miRNAs and lncRNAs are involved, as well as putative ncRNA regulation mechanisms, in erythropoiesis is essential for understanding the pathogenesis and design therapies for blood disorders, such as thalassemias.
Final report (in Greek)
Artemis- Georgia Hatzigeorgiou, Professor, Department of Electrical and Computer Engineering, University of Thessaly
John Strouboulis, Researcher, BSRC "Alexander Fleming"