Chromosome cohesin: linking ageing and the DNA damage response in mammalian oocytes
Department of Biological Applications & Technology, University of Ioannina
The increasing tendency of modern women to postpone childbearing has led to an increase in infertility, the development of pregnancies with chromosomal abnormalities and the pursuit for assisted reproductive treatments. Advanced maternal reproductive age has proven the main risk factor for genomic instability. Characteristically, the probability for the development of a trisomy rises from only 2% for a woman 20 years old to about 35% at 40 years of age. Chromosomally abnormal pregnancies can cause severe problems to maternal health, miscarriage and chronic infertility, while those resulting in live births may cause serious developmental disorders to the fetus. Major causes of the occurrence of chromosomal abnormalities are the loss of the cohesin complex but also the inefficient response to DNA damage in oocytes. With the study it is intended to identify in mammalian oocytes the role of cohesins and DNA damage in the development of age-dependent chromosomal abnormalities.
Final report (in Greek)
Petros Marangos, Assistant Professor, Department of Biological Applications & Technology, University of Ioannina
Rolf Jessberger, Professor and Director, Institute of Physiological Chemistry Dresden University of Technology