Development of new methodology for the production of nanofibers as controlled release systems for antibiotics
Faculty of Pharmacy, National and Kapodistrian University of Athens (EKPA)
The aim of the present proposal is the development of membranes from polygalactic acid (PLA) nanofibers that would allow the controlled release of antibiotics incorporated in them. Specifically, nanofibers of variable concentrations of PLA with different solvents will be produced and the dimensions, structure and surface area will be correlated with the electrospinning conditions (voltage, distance from collector, temperature) and polymer concentration using Scanning Electron Microscopy (SEM). A number of antibiotics will be incorporated in the nanofibers and the release rate of the antibiotics and their stability will be assessed with HPLC-DAD and LC-MS respectively. The antibacterial activity of the produced nanofiber membranes will be evaluated with the Kirby-Bauer method, while the position and the availability of the antibiotics will be measured by Χ-ray Photoelectron Spectroscopy (XPS).
Final Report (in Greek)
Vassilios Roussis, Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, National and Kapodistrian University of Athens (EKPA)
Dionysios Vynias, Research Associate, National and Kapodistrian University of Athens (EKPA)