Science

Programme "Scientific projects"

Cellular and neurochemical effects in the adult rat brain of a neonatal experience involving reward through maternal contact or its denial

Faculty of Nursing, School of Health Sciences, National and Kapodistrian University of Athens (EKPA)

2013

Early life experiences have a determinant role in shaping brain function and behavior. The team has developed a new model of an early experience in rats in which the expected reward through maternal contact is either received by the pup or denied to it (DER). It has been shown that the DER experience affects the dopaminergic and serotonergic systems in such a way as to result in hypofrontality with low dopamine in the prefrontal cortex (PFC) and deficits in a PFC-dependent behavioral task, depressive-like phenotype, proactive aggression and hyperactivity of the amygdala, indicating that this could be a good animal model of borderline personality disorder. In the present work, the team will determine in the PFC, the hippocampus and the amygdala the dendritic tree arborization and the number and morphology of the dendritic spines. Furthermore, the balance between the glutamatergic and the GABAergic systems will be examined at the cellular and biochemical level.

Final Report (in Greek)

Coordinator:

Fotini Stylianopoulou, Professor in Biology, Faculty of Nursing, School of Health Sciences, National and Kapodistrian University of Athens (EKPA)

Project's Team:

Efthymia Kitraki, Associate Professor, School of Dentistry, National and Kapodistrian University of Athens (EKPA)

Antonios Stamatakis, Assistant Professor in Biology - Biology of Behaviour, Faculty of Nursing, School of Health Sciences, National and Kapodistrian University of Athens (EKPA)

123, Papadiamantopoulou St.

11527 Goudi

Tel.: +30 210 74 61 598

Fax: +30 210 74 61 500

websitenurse@gmail.com

www.nurs.uoa.gr

menuShadow