Unique plant extracts derived from the Greek flora as potent pharmaceutical agents in the treatment of osteoporosis
Department of Dietetics and Nutritional Science, Harokopion University, Athens
Greece is well known for the richness and diversity of its flora and in particular, over 15% of Greek flora is endemic, meaning that it is not found anywhere else in the world. The World Health Organization is warning, that osteoporosis is becoming the second most frequent disease, after the cardiovascular diseases, and is therefore considered as a highly expanding health problem. The aim of the present study was the evaluation of plant extracts, derived from the Greek flora and which are widely consumed within the Mediterranean diet, on bone metabolism.
In this context, we studied the plants: Sideritis clandestina subsp. Clandestina and Sideritis clandestina subsp. Peloponnesiaca, known as ‘Mountain tea’, and the Cichorium spinosum, known as ‘stamnagathi’. These plants were collected from the Greek periphery, namely from Peloponnesus and Crete. The air-dried plant materials were powdered, extracted with appropriate solvents and concentrated to crude extracts. When we treated human osteoblasts with these plant extracts, we observed a significant inhibition of cell proliferation.
Conclusions: Herein, we show the unique characteristics and the biological activity of plant extracts derived from the Greek flora. Our data are very promising, regarding the application of these extracts in the field of osteoporosis.
Final report (in Greek)
Roxani Tenda, Lecturer, Department of Dietetics and Nutritional Science, Harokopion University, Athens
Nektarios Aliyiannis, Lecturer, School of Pharmacy, National and Capodistrian University of Athens
Maria Makropoulou, Doctoral Student, School of Medicine, National and Capodistrian University of Athens
Iphigeneia Bourgiezi, Undergraduate Student, Department of Dietetics and Nutritional Science, Harokopion University, Athens