Polycystic Ovarian Syndrome: Diet and Health
Faculty of Medicine, National and Kapodistrian University of Athens (EKPA)
Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy of women of reproductive age. It is characterized by hormonal abnormalities, reproductive dysfunction and infertility. The aim of the present study was to investigate the potential impact of fastfood diet (meals rich in glycotoxins, advanced glycation end products, AGEs) in the reproductive system of normal women and women with PCOS, in order to identify dietary solutions which will improve the metabolic and hormonal profile of these women.
The study consisted of 25 normal women of reproductive age and 25 women with PCOS who were allocated in different composition diets for two months-period (hypocaloric diet for two months followed by high-AGEs diet for two months and low-AGEs diet for the last two months). Measurements of biochemical parameters along with evaluation of hormonal and metabolic profile were performed before and after each dietary intervention.
During their low in glycotoxins content diet, women with PCOS presented a statistically significant drop of serum AGE levels (p=0.02), followed by a reduction in oxidative stress (p=0.01) as well as testosterone levels (p=0.05), without significant changes in body weight.
These findings point out the beneficial effect of low AGE diet in improving the hormonal profile and ameliorating the cardiovascular risk factors (e.g. oxidative stress) of women with PCOS suggesting its possible application in the dietary guidelines towards body weight loss.
Final report (in Greek)
Dr. Athanasios Papavasileiou, Professor, Biological Chemistry Laboratory, School of Medicine, National and Kapodistrian University of Athens
Dr. Evanthia Diamandi-Kandaraki, Assistant Professor, School of Medicine, National and Kapodistrian University of Athens
Dr. Christina Piperi, Lecturer, Biological Chemistry Laboratory, School of Medicine, National and Kapodistrian University of Athens
Dr. Ekaterini Papachroni, Post-doctoral Student, Biological and Chemical Laboratory, School of Medicine, National and Kapodistrian University of Athens
Christos Adamopoulos, Doctoral Student, Biological and Chemical Laboratory, School of Medicine, National and Capodistrian University of Athens