Science

Programme "Scientific projects"

Polycystic Ovarian Syndrome: Diet and Health

Faculty of Medicine, National and Kapodistrian University of Athens (EKPA)

2009

Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy of women of reproductive age. It is characterized by hormonal abnormalities, reproductive dysfunction and infertility. The aim of the present study was to investigate the potential impact of fastfood diet (meals rich in glycotoxins, advanced glycation end products, AGEs) in the reproductive system of normal women and women with PCOS, in order to identify dietary solutions which will improve the metabolic and hormonal profile of these women.

The study consisted of 25 normal women of reproductive age and 25 women with PCOS who were allocated in different composition diets for two months-period (hypocaloric diet for two months followed by high-AGEs diet for two months and low-AGEs diet for the last two months). Measurements of biochemical parameters along with evaluation of hormonal and metabolic profile were performed before and after each dietary intervention.

During their low in glycotoxins content diet, women with PCOS presented a statistically significant drop of serum AGE levels (p=0.02), followed by a reduction in oxidative stress (p=0.01) as well as testosterone levels (p=0.05), without significant changes in body weight.

These findings point out the beneficial effect of low AGE diet in improving the hormonal profile and ameliorating the cardiovascular risk factors (e.g. oxidative stress) of women with PCOS suggesting its possible application in the dietary guidelines towards body weight loss.

Final report (in Greek)

PHOTO GALLERY

Coordinator:

Dr. Athanasios Papavasileiou, Professor, Biological Chemistry Laboratory, School of Medicine, National and Kapodistrian University of Athens

Project's Team:

Dr. Evanthia Diamandi-Kandaraki, Assistant Professor, School of Medicine, National and Kapodistrian University of Athens

Dr. Christina Piperi, Lecturer, Biological Chemistry Laboratory, School of Medicine, National and Kapodistrian University of Athens

Dr. Ekaterini Papachroni, Post-doctoral Student, Biological and Chemical Laboratory, School of Medicine, National and Kapodistrian University of Athens

Christos Adamopoulos, Doctoral Student, Biological and Chemical Laboratory, School of Medicine, National and Capodistrian University of Athens

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